Prednisone acetate

Research use only, not for human use.

Prednisone acetate is a glucocorticoid receptor agonist with?immunomodulating properties and anti-inflammatory.

Prednisone acetate is a glucocorticoid receptor agonist with?immunomodulating properties and anti-inflammatory.

——

Animal Model:C57BL/6 mice Dosage:5 mg/kgAdministration:Intragastric gavage (i.g.)Result:Significantly failed to gain weight.Decreased the population spike (%) after high-frequency stimulation.Reduced the crossing times compared with the control group.Resulted in the impairment of memory, and caused a trend of more serious impairment. Reduced the levels of Glu and gamma-aminobutyric acid (GABA) in the hippocampus. Reduced the expressions of N-methyl-D-aspartate receptors in the hippocampus.Animal Model:Experimental autoimmune uveitis Dosage:6 mg/kg Administration:gavage Result:Showed fewer manifestations in eyes from day 9 after immunization. Reduced the inflammation in EAU rats. Bound with the pocket of Notch signaling-related molecules with good affinity. Exhibited anti-inflammatory effects through inhibiting Notch signaling activation.

Prednisone 21-acetate

Endocrinology/Hormones

GR

Glucocorticoid Receptor

Infection

Henoch-Sch?nlein Purpura Nephritis

125-10-0

400.46

C23H28O6

>98% (HPLC)

DMSO:25 mg/mL (62.43 mM; Need ultrasonic)

[H][C@@]12CC[C@](O)(C(=O)COC(C)=O)[C@@]1(C)CC(=O)[C@@]1([H])[C@@]2([H])CCC2=CC(=O)C=C[C@]12C

——

(-20℃)

With Ice Pack

≥ 2 years